The figures connect to inpatient or day cases, so don’t consist of emergency situation department admissions.
Of the 543 people treated last year, 351 were men and 192 were females.
There was a 19 percent increase in the number dealt with for alcohol dependence syndrome, or behaviour related to it.
The variety of people treated in healthcare facility for drug or alcoholism conditions increased by almost 10 percent in 2015.
In 2015, 438 people were dealt with for this factor, while the remainder were for other drug-addiction problems.
According to information launched under the Freedom of Information Act, 543 people had a primary diagnosis of a drug addiction when they were released from an Irish health center in 2018, compared to 498 the year before.
More than 1,000 people had inpatient remain in 2017 or 2018.
GP Hugh O’Donnell, a member of the Irish Medical Organisation, says there needs to be more awareness of the threats of illegal substances.